When the Saints (10-3) host the Colts (6-7) on “Monday Night Football” (8:15 p.m. ET, ESPN), it will be one NFC team trying to improve its playoff standing while one AFC team tries to keep its slim playoff hopes alive.

The Saints have some defensive injuries going into the game, while the Colts are getting a little healthier on offense. Indianapolis typically plays better at home, but has played unpredictable mostly close games everywhere this season.

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New Orleans has at times dominated teams with defense and special teams, other times rolling offensively with quarterback Drew Brees. Indianapolis has struggled to find an identity around quarterback Jacoby Brissett. The Saints and Colts both like slowing down games with efficient scoring and good running games.

Here’s everything to know about betting on Saints vs. Colts in Week 15, including updated odds, trends and our expert’s prediction for “Monday Night Football.”

MORE: Get the latest NFL odds & betting trends at Sports Insider

Saints vs. Colts odds for ‘Monday Night Football’

The line has been just short of double digits all week. The Saints are coming off a 2-point home loss in Week 14 to the 49ers. The Colts lost a road shootout to the Buccaneers by only 3 points.

Saints vs. Colts all-time series

The Saints lead the series 8-5. They have that edge by winning three in a row. The last time the teams played in New Orleans, the Saints rolled to a 62-7 win on a Sunday night in 2011. The Saints beat the Colts in Super Bowl 44, 31-17.

Three trends to know

— 60 percent of spread bettors are siding with the Saints. 60 percent of moneyline bettors also like the Saints.

— 68 percent of bettors like the game to go over the moderately high point total. The Colts have gone over in 8 of 13 games. The Saints have gone over in 7 of 13 games.

— The Saints have failed to cover in three of their past five games. The Colts have pushed and failed to cover in their previous two games.

Three things to watch

No Rankins or Davenport

The Saints usually have a stout front but now are playing without two key pieces in tackle Sheldon Rankins and end Marcus Davenport, who are both on season-ending injured reserve. That should help Brissett feel a little more comfortable, especially with end Cameron Jordan playing through an abdomen injury. Rankins’ absence in the middle on top of linebacker Kiko Alonso missing another game will help the Colts’ plan of power rushing a healthy Marlon Mack.

Yes Hilton

The Colts are set to have wide receiver T.Y. Hilton give it a go and play for the first time since Week 12. He likely will step into a tough matchup against cornerback Marshon Lattimore, but they have missed his field-stretching ability to open up the running game for Mack and the short passing game for Brissett.

Candid Kamara

Alvin Kamara has had a weird season for the Saints. The running back has scored only two touchdowns all season, both coming in Week 3. He has yet to record either 100 yards rushing or 100 yards receiving in a game in 2019. He doesn’t seem to be the same explosive, decisive player after his midseason ankle injury. The Saints need to get him going before going into the playoffs.

Stat that matters

The Saints are only 3-2 in home games with Brees this season but he’s been off the charts good in the Superdome as usual. In those 5 games, he’s completed nearly 75 percent of his passes, thrown for 13 TDs to only 3 INTs at 8.0 yards per attempt, 338 yards per game and a 112.6 passer rating.

Saints vs. Colts prediction

The Saints’ offense will make some big plays but it will be stalled a few times because of the bend-but-don’t-break nature of the Colts’ defense, which is still playing hard despite a few key injuries. That means a lot of red zone opportunities and moving the ball well but field goals to match the touchdowns. The Colts will work to run effectively to help Brissett keep in the game, but ultimately, they don’t score quite enough in another one-possession loss.

Saints 30, Colts 23

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